With 2 treatment regimens for advanced Hodgkin lymphoma equivalent in their long-term effectiveness, one regimen’s less severe side-effect profile may play a role in treatment choice, according to study results from the Gruppo Italiano di Terapie Innovative nei Linfomi and the Intergruppo Italiano Linfomi.
A combination of fludarabine, pixantrone, dexamethasone, and rituximab (FPD-R) achieved major durable responses in patients with relapsed or refractory indolent non-Hodgkin lymphoma (NHL) in a single-arm phase 1 dose-escalation study. The study identified a dose of 120 mg/m2pixantrone as the recommended dose for this regimen. The overall response rate with this regimen was 89%, and the regimen was well tolerated with no grade 3/4 cardiovascular adverse events. Grade 3/4 lymphopenia occurred, however, in 89% of patients and leukopenia in 79%.
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