Click Here to
News, Updates,
& More
Stay Up
to Date

Noninvasive Imaging Predicts Trastuzumab-Mediated Cardiomyopathy

Tissue velocity imaging and strain imaging can predict preclinical changes in left ventricular (LV) systolic function before a patient experiences a change in left ventricular ejection fraction (LVEF), according to a prospective study in HER2-positive patients receiving trastuzumab in the adjuvant setting. Cardiac biomarkers, however, did not predict the development of cardiac dysfunction. Based on these findings in 42 patients followed for 1 year, the researchers concluded that this ability to detect trastuzumab-mediated cardiotoxicity early with noninvasive imaging could benefit patients by allowing treatment adjustments and/or prophylactic administration before a patient developed irreversible cardiac dysfunction.


The complete study is published in the May 31, 2011, edition of the Journal of the American College of Cardiology (

Related Items
Oral Toxicities Associated with Cancer Therapies: What's Old Is New Again
Meg Barbor, MPH
Web Exclusives published on November 26, 2018 in Drug Therapies
Current Treatment Options for the Management of Glioblastoma Multiforme
Larry W. Buie, PharmD, BCPS, BCOP, John M. Valgus, PharmD, BCOP, CPP
JHOP - June 2012, Vol 2, No 2 published on July 6, 2012 in Drug Therapies
The Evolution of Tyrosine Kinase Inhibitor Therapy: Improving Outcomes in Patients with Newly Diagnosed Chronic Myelogenous Leukemia
Natalie J. Greisl, PharmD, Christopher A. Fausel, PharmD, BCPS, BCOP
JHOP - December 2011 VOL 1, NO 4 published on January 6, 2012 in Drug Therapies
Current Practice in the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting in Adults
Lisa K. Lohr, PharmD, BCOP, BCPS
JHOP - December 2011 VOL 1, NO 4 published on January 5, 2012 in Drug Therapies
A New Drug Therapy for HER2+ Breast Cancer May Be on the Horizon
TON - Daily published on July 27, 2011 in Drug Therapies
Postmenopausal Hormone Therapy Reduces Risk for Some Cancers
TOP - Daily published on June 15, 2011 in Drug Therapies
Hsp90 Inhibition Counters JAK/STAT-Signaling Diseases
TOP - Daily published on June 1, 2011 in Drug Therapies
Preoperative Anti-HER2 Agents Yield Benefits
Caroline Helwick
Web Exclusives published on December 23, 2010 in Drug Therapies, In the News
Last modified: April 27, 2020